facile one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,4-diones in ionic liquid and study of their antibacterial activities
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abstract
a simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([bmim]br) under solvent-free conditions is reported. the presented method is benefited from operational simplicity, simple workup and reusability of ionic liquid. these products were evaluated in vitro for their antibacterial activities.
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Journal title:
iranian journal of catalysisPublisher: islamic azad university, shahreza branch
ISSN 2252-0236
volume 3
issue 1 2013
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